The city of Jinan produces over 770 tons of hyaluronic acid annually, and has 
nurtured a group of leading enterprises such as Bloomage Biotech and Shandong 
Freda Biotech Co., Ltd. These enterprises represent the forefront of the 
industry, with levels of industrialization, output, and sales volume of 
hyaluronic acid that are among the highest in both China and the world.

Hyaluronic acid, a natural polysaccharide widely distributed in the 
extracellular matrix of animals and humans, used to be extracted from organisms 
such as cockscomb and bull's eye, which was inconvenient to produce and 
expensive. However, in the 1990s, microbial fermentation technology for 
producing hyaluronic acid was developed in Jinan Innovation Zone by Guo 
Xueping, the chief scientist and deputy general manager of Bloomage Biotech, 
and his team. This breakthrough significantly reduced the production cost of 
hyaluronic acid, enabling mass production in China and global supply. In 2011, 
the R&D team of Bloomage Biotech pioneered the "enzyme cutting" technique for 
large-scale production of low-molecular oligomeric hyaluronic acid, expanding 
its application to fields such as contact lens solutions, family planning 
supplies, cosmetics and toiletries. As of 2021, China's global market share of 
hyaluronic acid raw materials has increased to over 87%, establishing an 
industrial pattern where "the world looks to China for hyaluronic acid, and 
China looks to Jinan for hyaluronic acid."

According to the Information Office of Jinan Municipal People's Government, 
over the course of 20 years, Jinan has built a globally competitive industry. 
Now, Jinan is setting its sights on a more dynamic industrial ecosystem and a 
longer-term industrial vision. To this end, Jinan Innovation Zone and Bloomage 
Biotech will collaborate to create the Global Hyaluronic Acid Valley, which 
will encompass innovative drugs, high-end medical devices, functional skincare 
products, financial investments, and more. The total investment for this 
project will exceed 24 billion yuan.

Source: Information Office of Jinan Municipal People's Government

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   Link: https://iop.asianetnews.net/view-attachment?attach-id=442335

   Caption: Media reporters from various countries visited Bloomage Biotech.