Country for PR: United States
Contributor: PR Newswire New York
Monday, June 10 2019 - 22:00
AsiaNet
Collaborative Medicinal Development, LLC Reports that Lead Drug Shows Dose-Dependent Improvement in Parkinson's Disease
MILL VALLEY, California, June 10, 2019 /PRNewswire-AsiaNet/ --

Collaborative Medicinal Development LLC ("CMD"), a privately-held 
biopharmaceutical company developing innovative therapies for neurodegenerative 
diseases, will report promising results from its phase 1, non-placebo 
controlled, dose-finding study of CuATSM for treatment of Parkinson's Disease 
("PD") at the XXIV World Congress on Parkinson's Disease and Related Disorders 
to be held in Montreal, Canada from June 16-19, 2019. In a presentation, Dr. 
Craig Rosenfeld, CMD's CEO, will report the results of 24 weeks of treatment 
with CuATSM at the recommended phase 2 dose. Patients with idiopathic PD showed 
a marked improvement in disease severity evidenced by a decrease in total UPDRS 
score of 7 points over 24 weeks.  Patients also showed a marked improvement in 
quality of life evidenced by a decrease in PDQ-39 score of 15 points over 24 
weeks; a 5 point change in PDQ-39 is considered the threshold for a clinically 
meaningful change.  In the natural history of PD, both UPDRS and PDQ-39 scores 
increase (worsen) in correlated fashion over time.

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About Collaborative Medicinal Development
CMD is a privately-held biopharmaceutical company developing innovative 
therapies for neurodegenerative diseases.  The Company's lead drug, CuATSM, was 
licensed from the University of Melbourne and entered clinical trials in ALS 
and Parkinson's disease in 2017 at leading clinical centers in Australia. The 
CMD team includes Craig Rosenfeld, MD (CEO) and  Kay Noel, PhD (COO). 

About Parkinson's Disease (PD)
PD is a slowly progressing neurodegenerative disorder with early prominent 
death of dopaminergic neurons in the substantia nigra. The resultant dopamine 
deficiency within the basal ganglia leads to a movement disorder characterized 
by classical parkinsonian motor symptoms, including bradykinesia, muscular 
rigidity, rest tremor, and postural and gait impairment. While there are 
treatments available for many of the parkinsonian motor symptoms, 
disease-modifying treatments that reduce the rate of neurodegeneration or stop 
the disease process have remained elusive and are the greatest unmet 
therapeutic need in PD.

Contact Information
For further Information
Rory Hill, Business Development
RoryH@Cthulhu.com 

SOURCE: Collaborative Medicinal Development, LLC