-- The T Cell Receptor Sequencing Kit (TCRseq Kit) allows users of Berkeley 
Lights platforms to more efficiently identify, recover, and sequence T cells of 
interest 

Today, Berkeley Lights, a leader in cell selection, launched their new T Cell 
Receptor Sequencing Kit (TCRseq Kit). The TCRseq Kit enables users of Berkeley 
Lights' Beacon and Lightning instruments to recover functionally validated T 
cell receptors (TCRs) from a cell sample that has as few as 10,000 input cells. 
The TCRseq Kit enables Berkeley Lights platform users to first characterize the 
T cell function using the Berkeley Lights Cell Therapy Development Suite and 
then only sequence the T cells that matter. This therefore functionally 
replaces existing methodologies that require re-expressing hundreds of TCRs in 
the hopes of identifying the rare sequence that imparts an ideal specificity.

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"We're excited to announce the launch of the TCRseq Kit, an advanced tool that 
enables recovery of alpha/beta chain sequences specific TCRs from single cells 
and increases TCR recovery to over 70%," said John Proctor, Ph.D., Senior Vice 
President of Marketing at Berkeley Lights. "We are building a Cell Therapy 
Development Suite of tools to help our customers better characterize T cells 
with the Beacon and Lightning instruments."

After performing a T cell functional assay on the Beacon or Lightning 
instrument, the user selects single human T cells of interest and exports them 
from the company's OptoSelect chip to a well plate. Using reagents provided in 
the TCRseq Kit, RNA from single T cells is recovered and V(D)J regions of the 
TCR alpha and beta chains are amplified. The resulting cDNA is ready for the 
user to index and sequence using sequencing platforms. The TCRseq Kit includes 
reagents and protocols for processing up to 192 single human T cells.

The TCRseq Kit is available for purchase now. You can find more information 
here: https://www.berkeleylights.com/applications/t-cell-functional-analytics 

About Berkeley Lights 
Here at Berkeley Lights, we think cells are awesome! Cells are capable of 
manufacturing cures for diseases, fibers for clothing, energy in the form of 
biofuels, and food proteins for nutrition. So the question is, if nature is 
capable of manufacturing the products we need in a scalable way, why aren't we 
doing more of this? Well, the answer is that with the solutions available 
today, it is hard. It takes a long time to find the right cell for a specific 
job, costs lots of money, and if you have picked a suboptimal cell line, has a 
very low process yield. Berkeley Lights has the complete solution to find the 
best cells by functionally screening and recovering individual cells for 
antibody discovery, cell line development, T cell analysis, and synthetic 
biology. Our proprietary technology and Beacon(R) and Lightning(TM) platforms 
accelerate the rate you can discover and develop cell-based products in a 
fraction of the time and at a fraction of the cost of conventional, legacy 
research methods. Using our tools and solutions, scientists can find the best 
cells, the first time they look. For more information, visit 
www.berkeleylights.com.

Berkeley Lights' Beacon and Lightning instruments and the TCRseq Kit are: For 
Research Use Only. Not for use in diagnostic procedures. 

SOURCE Berkeley Lights

CONTACT: berkeleylights@bulleitgroup.com