-- Early Release of the VirSieve(TM) Bioinformatics Pipeline Will 
     Promote Collaboration in Environmental SARS-CoV-2 Research

Zymo Research has released the VirSieve(TM) Bioinformatics Pipeline ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=1828882666&u=https%3A%2F%2Fwww.zymoresearch.com%2Fpages%2Ftools%3Futm_source%3DPRNewswire%26utm_medium%3DPress_Release%26utm_campaign%3DVirsieve_Press_Release_5.11.21%26utm_content%3DVirsieve_link&a=VirSieve%E2%84%A2+Bioinformatics+Pipeline 
) source code to the environmental microbiology community to promote global 
collaboration and support for the detection of SARS-CoV-2 variants in 
wastewater. VirSieve(TM) is an automated computational pipeline that analyzes 
sequencing reads from the SARS-CoV-2 virus in wastewater samples to better 
understand viral variants present in monitored communities. By rating the 
confidence interval in observed viral mutations, the software has the potential 
to significantly increase the accuracy of analyzing any changes in the viral 
genetic material.

Photo - 
https://mma.prnewswire.com/media/1507133/Wastewater_PR_data_on_computer_2000x1111px.jpg 

Logo - https://mma.prnewswire.com/media/364743/Zymo_Research_Corp_Logo.jpg 

According to the Centers for Disease Control and Prevention, while the 
deployment of vaccines has had a tremendous positive impact on curbing the 
SARS-CoV-2 pandemic within the USA, new viral strains are still emerging. Some 
of these strains, e.g., B.1.1.7, are classified as "variants of concern" due to 
evidence of increased spread, pathogenicity, or vaccine evasion. Wastewater 
Next-Gen Sequencing is emerging as the most viable solution for near real-time 
community surveillance.

Viral sequencing from wastewater is difficult due to fragmentation and 
degradation of the viral RNA, often resulting in sequencing errors that 
ultimately manifest as false mutations. VirSieve(TM) can identify these false 
variants and mark them as being low or no confidence, allowing researchers to 
filter mutations with a higher degree of support. Zymo Research also provides 
DNA/RNA Shield(TM) ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=3877216847&u=https%3A%2F%2Fwww.zymoresearch.com%2Fpages%2Fshield-510k%3Futm_source%3DPRNewswire%26utm_medium%3DPress_Release%26utm_campaign%3DVirsieve_Press_Release_5.11.21%26utm_content%3DShield_link&a=DNA%2FRNA+Shield 
), a reagent that safeguards viral RNA from further degradation after 
inactivation of any virus for safe, ambient temperature collection and 
transportation of wastewater samples.

"Zymo Research has previously developed public software tools like the Zymo 
Research Transmit Program, an open-source client for submitting COVID-19 test 
results through the CalREDIE public health reporting system," said Dr. Michael 
Weinstein, Director of Laboratory Information Systems, and Project Lead on the 
VirSieve(TM) Pipeline project at Zymo Research. "VirSieve(TM) is part of Zymo 
Research's ongoing effort to provide maximum support to pandemic response 
efforts around the globe. We feel VirSieve(TM) has the potential to be used not 
only for tracking variant strains of the SARS-CoV-2 virus in wastewater but 
other viruses as well, for future public health efforts."

"Getting accurate variants from clinical samples or sewage is key to proper 
placement of a viral strain in the context of all other viral variants and 
informing pathogen tracking efforts," said Dr. Christopher Mason, who is a paid 
speaker for Zymo Research and is the co-director of the WorldQuant Institute 
for Quantitative Prediction and a professor of physiology and biophysics at 
Weill Cornell Medicine.

For more information about the VirSieve(TM) Pipeline visit Zymo Research's 
website ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=782156607&u=https%3A%2F%2Fwww.zymoresearch.com%2Fpages%2Ftools%3Futm_source%3DPRNewswire%26utm_medium%3DPress_Release%26utm_campaign%3DVirsieve_Press_Release_5.11.21%26utm_content%3DVirsieve_link&a=website 
) or contact them via email at tech@zymoresearch.com.

About Zymo Research Corp.
Zymo Research is a privately owned company that has been serving the scientific 
and diagnostics community with state-of-the-art molecular biology tools since 
1994. "The Beauty of Science is to Make Things Simple" is their motto, which is 
reflected in all of their products, from epigenetics to DNA/RNA purification 
technologies. Historically recognized as the leader in epigenetics, Zymo 
Research is breaking boundaries with novel solutions for sample collection, 
microbiomic measurements, diagnostic devices, and NGS technologies that are 
high quality and simple to use. Follow Zymo Research on Facebook ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=1560820644&u=https%3A%2F%2Fwww.facebook.com%2Fzymoresearch&a=Facebook 
), LinkedIn ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=4214918074&u=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fzymo-research-corp%2F&a=LinkedIn 
), Twitter ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=998048982&u=https%3A%2F%2Ftwitter.com%2FZymoResearch&a=Twitter 
), and Instagram ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=954977888&u=https%3A%2F%2Fwww.instagram.com%2Fzymoresearch%2F&a=Instagram 
).

For more information about Zymo Research's COVID-19 products, check out the 
following links:

  - Zymo Research Releases Free Software to Streamline COVID-19 Test Reporting 
( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=45936501&u=https%3A%2F%2Fwww.prnewswire.com%2Fnews-releases%2Fzymo-research-releases-free-software-to-streamline-covid-19-test-reporting-301100732.html%3Ftc%3Deml_cleartime&a=Zymo+Research+Releases+Free+Software+to+Streamline+COVID-19+Test+Reporting 
) 
  - Zymo Research Obtains CE IVD Mark for its Quick SARS-CoV-2 Multiplex Kit ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=2951363091&u=https%3A%2F%2Fwww.prnewswire.com%2Fin%2Fnews-releases%2Fzymo-research-obtains-ce-ivd-mark-for-its-quick-sars-cov-2-multiplex-kit-842686546.html&a=Zymo+Research+Obtains+CE+IVD+Mark+for+its+Quick+SARS-CoV-2+Multiplex+Kit 
) 
  - Zymo Research Obtains Emergency Use Authorization from FDA for Their Quick 
SARS-CoV-2 rRT-PCR Kit ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=1173173430&u=https%3A%2F%2Fwww.prnewswire.com%2Fnews-releases%2Fzymo-research-obtains-emergency-use-authorization-from-fda-for-their-quick-sars-cov-2-rrt-pcr-kit-301057233.html&a=Zymo+Research+Obtains+Emergency+Use+Authorization+from+FDA+for+Their+Quick+SARS-CoV-2+rRT-PCR+Kit 
) 
  - Zymo Research Receives CE IVD Mark for its Quick-DNA/RNA(TM) Viral MagBead 
Kit ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=3953568726&u=https%3A%2F%2Fwww.prnewswire.com%2Fin%2Fnews-releases%2Fzymo-research-receives-ce-ivd-mark-for-its-quick-dna-rna-tm-viral-magbead-kit-803100122.html&a=Zymo+Research+Receives+CE+IVD+Mark+for+its+Quick-DNA%2FRNA%E2%84%A2+Viral+MagBead+Kit 
) 
  - Zymo Research Launches COVID-19 Sequencing Service for the Detection and 
Surveillance of Emerging SARS-CoV-2 Variants ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=1923697244&u=https%3A%2F%2Fwww.prnewswire.com%2Fnews-releases%2Fzymo-research-launches-covid-19-sequencing-service-for-the-detection-and-surveillance-of-emerging-sars-cov-2-variants-301226557.html%3Ftc%3Deml_cleartime&a=Zymo+Research+Launches+COVID-19+Sequencing+Service+for+the+Detection+and+Surveillance+of+Emerging+SARS-CoV-2+Variants 
) 
  - Zymo Research Offers Community-Wide SARS-CoV-2 Detection and Variant 
Tracking with the Environ(TM) COVID-19 Wastewater Testing Service ( 
https://c212.net/c/link/?t=0&l=en&o=3158697-1&h=194802337&u=https%3A%2F%2Fwww.prnewswire.com%2Fnews-releases%2Fzymo-research-offers-community-wide-sars-cov-2-detection-and-variant-tracking-with-the-environ-covid-19-wastewater-testing-service-301240237.html%3Ftc%3Deml_cleartime&a=Zymo+Research+Offers+Community-Wide+SARS-CoV-2+Detection+and+Variant+Tracking+with+the+Environ%E2%84%A2+COVID-19+Wastewater+Testing+Service 
) 
  - Zymo Research Receives 510(k) Clearance for its Collection/Transport Device 
for COVID-19 ( 
https://www.prnewswire.com/news-releases/zymo-research-receives-510k-clearance-for-its-collectiontransport-device-for-covid-19-301245240.html?tc=eml_cleartime 
)

Source - Zymo Research Corp.

CONTACT: Marketing Department, Zymo Research Corp., 949.679.1190,  
marketing@zymoresearch.com