Eucure Biopharma will present findings from two Phase I clinical trials at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, held from June 4th to 8th. Logo - https://mma.prnewswire.com/media/1358305/Biocytogen_Logo.jpg The first trial (poster #2580; NCT04481009) is designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor efficacy of YH003 (an anti-CD40 monoclonal antibody (mAb)) combined with Toripalimab (Tuoyi(R); an anti-PD-1 mAb) in subjects with advanced solid tumors. As of December 31, 2020, there were no dose-limiting toxicity (DLT) events or severe adverse events (AE) observed in 9 subjects/3 dose levels (ranging from 0.03 to 0.3 mg/kg). Of the 5 subjects that completed at least one tumor assessment, one subject with ocular melanoma who failed prior Opdivo and Opdivo/Yervoy combination therapy achieved partial remission (PR), and two patients maintained stable disease (SD). The second trial (poster #2577; NCT04357756) is a Phase I clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary anti-tumor efficacy of an anti-CTLA-4 antibody, YH001, combined with Toripalimab in subjects with advanced solid tumors. As of December 31, 2020, no DLT or severe AE were observed at 4 dose levels (ranging from 0.05 to 1 mg/kg). Seven of 10 subjects completed at least one tumor assessment, of which 4 subjects maintained SD. As of March 1, 2021, one subject with GEJ cancer that maintained SD in the first tumor assessment achieved PR in the second assessment, with a 60.9% reduction in the target lesion compared to baseline. About YH003 YH003 is a humanized IgG2 agonistic monoclonal antibody that targets CD40 signaling. Preclinical studies demonstrated that YH003 promotes antigen-presenting cell activation and infiltration of effector T cells into tumors. YH003 demonstrated potent anti-tumor effects in Biocytogen's ( https://c212.net/c/link/?t=0&l=en&o=3182072-1&h=1200295960&u=http%3A%2F%2Fwww.biocytogen.com%2F&a=Biocytogen ) humanized CD40 mice ( https://c212.net/c/link/?t=0&l=en&o=3182072-1&h=4248054923&u=https%3A%2F%2Fbiocytogen.com%2Fproducts%2Fhumanized-immune-checkpoint-mice%2Fb-hcd40-mice%2F&a=humanized+CD40+mice ), both alone and in combination with anti-PD-1 monoclonal antibodies. YH003 has been approved to enter Phase II trials in Australia for pancreatic cancer and PD1-resistant melanoma. About YH001 YH001 is a humanized IgG1 monoclonal antibody that blocks the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) with CD80/CD86. YH001 can trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) to remove CTLA-4 expressing cells, especially regulatory T cells, to enhance T-cell-mediated antitumor immune responses. Preclinical data indicates that YH001 outperforms Ipilimumab (a currently approved CTLA-4 drug) in CTLA-4 binding affinity and inducing ADCC activity. About Eucure Biopharma Eucure Biopharma is a biopharmaceutical company focused on the development of innovative immunotherapies to meet clinical needs of patients around the world. Relying on a strong clinical development team with extensive experience, the company has established a product pipeline for more than 10 targets. Eucure Biopharma is a wholly owned subsidiary of Biocytogen ( https://c212.net/c/link/?t=0&l=en&o=3182072-1&h=1200295960&u=http%3A%2F%2Fwww.biocytogen.com%2F&a=Biocytogen ). For more information, please visit www.eucure.com. Media Contact: Eucure Biopharma Yuanyuan Li yuanyuan.li@bbctg.com.cn SOURCE Biocytogen