- Significant milestone in the only late-stage clinical trial targeting tau 
pathology of Alzheimer's

- TauRx on track to announce top line results in May

- Trial aims to confirm efficacy of first tau-based treatment for Alzheimer's 

TauRx Pharmaceuticals Ltd, a global leader in tau-based Alzheimer's Disease 
(AD) research, has announced that the last patient has completed treatment in 
the blinded phase of their late-stage clinical trial, Lucidity (NCT03446001).

This milestone means TauRx will now progress to the data cleaning and analysis 
phase which enables the company to determine topline results on the safety and 
efficacy of Hydromethylthionine mesylate (HMTM). The topline results are due to 
be announced in May.

Professor Claude Wischik, Executive Chairman and Co-Founder, said: "AD is a 
leading cause of death in the UK and one of the world's greatest unmet medical 
needs. At TauRx, we've focused our efforts over the last few decades to 
developing an effective treatment for this devastating disease based on 
targeting the tau pathology which is the main driver of clinical dementia. 

"This milestone takes us one step closer to announcing the topline results of 
our potentially ground-breaking Lucidity study. We're extremely grateful to all 
who are progressing the trial; the study coordinators and investigators, and 
most importantly the patients who volunteered to take part."

According to AD International, around 50 million people are affected by 
dementia worldwide, and in 2050 this will rise to 152 million – with AD being 
the most common form. 

Lucidity is the only late-stage clinical trial specifically targeting the tau 
pathology of AD. Aggregation of abnormal tau is a hallmark of AD. Tau 
aggregation and the formation of tau tangles disrupt neuronal function, a 
process that begins years before dementia symptoms are seen. Tau pathology 
correlates strongly with AD severity and the clinical decline commonly seen in 
patients. 

ABOUT

TauRx's mission is to discover, develop and commercialise innovative products 
for the diagnosis, treatment and cure of neurodegenerative diseases caused 
through protein aggregation. The company's drug research targets the misfolding 
and formation of tau aggregates that form inside nerve cells in the brain, 
playing a role in the disease pathology of Alzheimer's and other dementias. 
Headquarters are in Singapore and primary research facilities and operations 
are in Aberdeen. 

https://taurx.com/
https://www.luciditytrial.com/ 

Source: TauRx Pharmaceuticals Ltd